Introduction: Even though there´s abundant literature about alcohol consumption and self-esteem, the results are still contradictory. Objective: to make a systematic review and meta-analysis which analyzes the role that self-esteem plays in alcohol consumption in Latino adolescents. Method: A systematic review was made with meta-analysis, based on Copper´s recommendations (2009) and PRISMA protocol. The literatura search was conducted in the electronic database which are especially recognized in the area of health: PUBMED, LILACS, SCOPUS and EBSCO. Resultados: 140 primary articles were identified, they were evaluated through title, summary and finally through full text and in the end 8 articles were selected for the review and meta-analysis. A defect size was reported (Z = - 4.404247, p < 0.0001) and a grouped correlation of r = -0.073. Discussion and conclusion. Self-esteem is related negatively and significantly to alcohol consumption in Latino adolescents.