This article aims to validate the possibility of including technology from micobiologies and synthetic biology in architecture and design. For this analysis, five projects are presented: a project of our own, developed by the research group, another with a direct application in architecture and three additional projects form the world of microbiology, which review topics such as energy generation, materials production and improving air quality thought microorganisms. This analysis, aims to legitimate, and expose the advantages and limits of a potential union between the molecular world and the design of the habitable space.