Entrepreneurship is recognized as an engine for the economy. However, Latin America must promote higher opportunities for the creation of new businesses, especially for technology-based ventures. In this sense, the Center for Global Innovation and Entrepreneurship (CGIE) of the University of Texas at Austin offers a Master of Science in Technology Commercialization (MCCT) that prepares students with methodologies to promote the creation of new businesses in Mexico. This study aims to know the contribution of training to the creation of new companies, and its role in the innovation and the technology transfer processes, from the viewpoint of the participants. This research presents a case study that analyzes the impact of the MCCT through the analysis of the data of a survey answered by 109 former students of this center. Findings show that the methodologies developed by the MCCT allow the creation of technology-based enterprises and entrepreneurial skills in students. This study presents good practices that can be emulated by other countries in the region, as well as recognizing the great value the role of higher education in creating synergies between actors of the innovation ecosystem that strengthen social and economic growth